副教授 杜波

职称职务：副教授  学科专业：遗传学  研究方向：水稻抗褐飞虱基因发掘与应用  实验室位置：当代楼1号楼3楼     电话/Tel:86-18986005009     Email: bodu@whu.edu.cn

教育经历/Education

2003/09-2009/12，武汉大学，博士/Wuhan University, PhD

2001/09-2003/07，武汉大学，硕士/Wuhan University, Master's Degree

1997/09-2001/07，武汉大学，学士/Wuhan University, Bachelor's Degree

工作经历/Professional Experience

2010/07-至今，武汉大学生命科学学院/College of Life Sciences, Wuhan University; 

奖励荣誉/Awards and Honors

2021年，国家技术发明二等奖

2021年，湖北专利奖银奖

2017年，湖北省技术发明一等奖

研究方向/Research Fields

1) 水稻抗虫基因的克隆及功能分析/Functional analysis and map-based cloning of insect resistance genes in rice;

2) 植物与昆虫的相互作用机制/Plant-insects interaction and its regulation mechanism;

研究概述/Research Description

  杜波老师主要从事水稻抗褐飞虱基因的克隆与功能分析、水稻抗虫分子机理以及抗虫品种的培育和利用的研究。他在国际上成功克隆了第一个水稻抗褐飞虱基因，首次揭示了植物抗虫基因编码一个受体蛋白的本质。后续又克隆水稻抗褐飞虱基因Bph6，揭示了BPH6与胞泌复合体亚基互作调控水稻抗虫的分子机理。通过克隆抗褐飞虱基因、创制抗虫新种质、开发功能标记和建立抗虫鉴定方法，创建了水稻抗褐飞虱分子育种技术体系，并制定了湖北省地方标准——水稻抗褐飞虱抗性鉴定技术规程。近期，开始关注非编码RNA在水稻抗病虫中的功能研究。

     Dr. Du focuses on the research about the clone and function of insect resistance gene, resistance molecular mechanism, and breeding and utilization of resistant varieties in rice.  Dr. Du successfully cloned the first brown planthopper resistance gene in the world, and revealed the essence of a receptor protein encoding plant resistance gene.  Subsequently, he characterized the other insect resistance gene, Bph6, and elucidated the molecular mechanism, which interacted the subunit of exocyst complex to regulate resistance of rice.  Dr Du established the molecular breeding technology system for brown planthopper resistance in rice, and designed the technical specification for resistance to brown planthopper in rice, a local standard of Hubei Province through cloning the insect resistance genes, creating new germplasm, developing functional markers and establishing identification methods for insect resistance.   Recently, the attention of Dr Du has been paid to the function of non-coding RNA in rice resistance to disease and insect pests.  

科研项目/Rresearch Project

2018-2020，国家转基因新品种培育重大专项，抗褐飞虱转基因水稻新品种培育（2018ZX08001-01B），主持

2015-2016，国家自然科学基金面上项目，水稻抗褐飞虱调控途径重要基因的克隆及功能分析（31470102），主持

2011-2013，国家自然科学基金面上项目，水稻抗褐飞虱基因Bph14作用的分子机理研究（31071059），主持

代表性学术论文/Selected Publications

1) Bo Du, Weilin Zhang, Bingfang Liu, Jing Hu, Zhe Wei, Ruifeng He, Lili Zhu, Rongzhi Chen, Bin Han, Guangcun He*. (2009) Identification and characterization of Bph14, a gene conferring resistance to brown planthopper in rice. Proc Natl Acad Sci USA 106: 22163–22168.

2) Guo Jianping#, Xu Chunxue#, Wu Di#, Zhao Yan, Qiu Yongfu, Wang Xiaoxia, Ouyang Yidan, Cai Baodong, Liu Xin, Jing Shengli, Shangguan Xinxin, Wang Huiying, Ma Yinhua, Hu Liang, Wu Yan, Shi Shaojie, Wang Wenliang, Zhu Lili, Xu Xun, Chen Rongzhi, Feng Yuqi, Du Bo*, He Guangcun*. (2018). Bph6 encodes an exocyst-localized protein and confers broad resistance to planthoppers in rice. Nature Genetics, 304: 297-306.

3) Ma Yinhua, Zhao Yan, Shangguan Xinxin, Shi Shaojie, Zeng Ya, Wu Yan, Chen Rongzhi, You aiqing, Zhu Lili, Du Bo*, He Guangcun*. (2017). Overexpression of OsRRK1 Changes Leaf Morphology and Defense. Frontiers in Plant Science, 8: 1783.

4) Du Bo, Chen Rongzhi, Guo Jianping, He Guangcun*. (2020).Current understanding of the genomic, genetic, and molecular control of insect resistance in rice. Molecular Breeding 41: 24.

5) Tan Jiaoyan, Wu Yan, Guo Jianping, Li Huimin, Zhu Lili, Chen Rongzhi, He Guangcun, Du Bo*. (2020). A combined microRNA and transcriptome analyses illuminates the resistance response of rice against brown planthopper. BMC Genomics, 40: 144.